PREMIUM TREATMENT
Tirzepatide Plus+
average 22.5% body weight loss
$399/mo
HSA / FSA Eligible
Premium GLP-1 blend featuring a full dose of Tirzepatide, enhanced with Niacinamide (Vitamin B3) to support weight loss and boost energy levels.
Same active ingredient as Mounjaro® & Zepbound®
Premium, personalized blend with better results than Tirzepatide
In stock: Same day prescriptions and free overnight shipping
Each batch of medication undergoes extensive quality checks
What is Tirzepatide Plus?

Meet Tirzepatide Plus, our advanced weight loss formula that combines the cutting-edge power of Tirzepatide with Niacinamide (Vitamin B3) to enhance your health and wellness. Specifically compounded for Willow patients, this innovative blend offers more than just weight loss.

While Tirzepatide works to regulate blood sugar, suppress appetite, and promote fat loss, Niacinamide provides targeted support for your weight loss journey. It helps improve energy production, supports healthy metabolism, and enhances skin health, ensuring you feel and look your best as you achieve your goals.

Tirzepatide Plus offers a holistic approach to weight loss, helping you shed pounds effectively while supporting overall vitality and wellness.

CA, WI, and IA residents will receive Tirzepatide Plus with L-Carnitine. This GLP-1 blend features a full dose of Tirzepatide, enhanced with L-Carnitine to support weight loss and preserve lean muscle mass.

What are the benefits of Niacinamide (Vitamin B3)?

Niacinamide, a form of Vitamin B3, is a vital nutrient that plays a key role in energy production, metabolism, and cellular repair. It supports your body’s natural ability to convert food into energy and helps maintain healthy skin, reduce inflammation, and promote overall wellness. This makes Niacinamide an excellent addition for those looking to enhance their weight loss and health journey.When combined with tirzepatide, Niacinamide offers a comprehensive approach to weight management.

While tirzepatide helps regulate blood sugar levels and suppress appetite, Niacinamide supports your body's metabolic processes, ensuring sustained energy and promoting a healthy balance throughout your journey. This combination not only aids in effective and steady weight loss but also supports cellular health and overall vitality. Together, tirzepatide and Niacinamide work synergistically to help you achieve your weight loss goals while enhancing your overall health and well-being.

What is the difference between Semaglutide and Tirzepatide?

Semaglutide and tirzepatide are both medications used for weight loss, but they have distinct differences.

Semaglutide is a GLP-1 receptor agonist, which helps to regulate blood sugar by enhancing insulin secretion, slowing gastric emptying, and promoting satiety.

Tirzepatide, on the other hand, is a dual agonist, targeting both the GLP-1 and GIP receptors, offering enhanced glucose control and weight loss by combining the effects of both incretin hormones. Clinical trials suggest that tirzepatide offers superior efficacy in both glucose lowering and weight reduction compared to semaglutide.

Lose 20% of body weight with weight loss that feels natural
The science behind Tirzepatide Plus

Tirzepatide is a novel medication that works by targeting two key receptors involved in glucose and energy regulation: the glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor.

By activating these receptors, Tirzepatide enhances insulin secretion in response to meals, inhibits glucagon release, and slows gastric emptying, which helps to control blood sugar levels. Additionally, it promotes feelings of fullness and reduces appetite, leading to weight loss.

The dual agonist action of Tirzepatide leverages the complementary effects of GLP-1 and GIP, resulting in improved glycemic control and significant weight reduction in patients.

How does it feel to take Tirzepatide Plus?
No more random snack cravings throughout the day
Smaller portions feel just as satisfying as large ones used to
The feeling of being full lasts longer after meals
Dieting feels natural and weight loss seems effortless

How Willow works

01
Take the quiz
Start with a 2-min assessment quiz to get pre-approved instantly.
02
Choose your plan
Share your health history, choose a plan, and get a same-day prescription from a US doctor.
03
Transform your life
Get monthly weight loss medication with free shipping and support from board-certified doctors.

Our medical team

As a Willow patient, you’ll be supported along your entire weight loss journey by our medical team of board certified doctors.
Have a question? Get answers and guidance with unlimited same-day doctor messaging. Our team is with you every step of the way.
Dr. Michael Green
MD, OB/GYN

Why Willow?

Ready to transform your life with Tirzepatide Plus? Willow offers transparent pricing, high-quality medication, and dedicated support.
Starts at $399 per month. Includes prescription, medication, and free overnight shipping.
Same-day prescriptions with no insurance required.
Unlimited same-day messaging and support from US-based board-certified doctors.

Worried about side effects?

Some patients may experience side effects while on Tirzepatide. The most common ones is nausea. While these side effects can be bothersome, the good news is that they usually subside over time.

Your doctor will help find the best treatment, gradually increasing the dosage for weight loss and comfort. If you have any issues, they’ll adjust the plan. Just send a message! — No appointment required.

Your doctor can also prescribe generic Zofran (Ondansetron) if needed. This optional anti-nausea medication can help with side effects.

Game-changing weight loss medication


Results could mark a "new era" in treating obesity with even more therapies on the horizon.


The most effective drug intervention we have seen for weight management.


In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.


2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.


These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.

1
1


Results could mark a "new era" in treating obesity with even more therapies on the horizon.


The most effective drug intervention we have seen for weight management.


In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.


2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.


These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.

1
1


Results could mark a "new era" in treating obesity with even more therapies on the horizon.


The most effective drug intervention we have seen for weight management.


In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.


2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.


These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.

1
1

Questions we hear everyday

Do I need to make changes to my diet with Compound Tirzepatide?

We believe in a sustainable and flexible approach to nutrition, without imposing limitations on your diet. Our goal is to guide you in establishing healthy eating habits, complemented by the medication's ability to decrease appetite and “food noise”. We encourage maintaining a nourishing, high-protein diet, but most patients are able to lose weight without the need for uncomfortably restrictive dieting or calorie counting.

What are the side effects for Tirzepatide?

Common side effects of tirzepatide are usually mild and may include:

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Abdominal pain

• Decreased appetite

• Indigestion


The majority of side effects are transient and typically resolve spontaneously. Nevertheless, if side effects persist or deteriorate, seek guidance from a healthcare professional.

Willow also offers Odansetron to manage side effects if they occur. This medication is commonly used to prevent nausea and vomiting.

Tirzepatide Patient Safety Information

What happens if I stop the medication?

When stopping  Tirzepatide abruptly, some patients may experience mild to moderate weight gain. Others may maintain the weight loss they achieved while on the medication. We recommend patients work with their Willow physician to slowly decrease their dose in order to maintain their weight loss achievements.

You may notice an increase in appetite and a return of food cravings, allowing you to eat more without feeling as full. However, stopping Tirzepatide is a safe and common practice that doesn't involve serious health risks. By gradually tapering off the medication with your physician’s guidance, you can better manage these changes and maintain your health and wellness goals.

How do I take Tirzepatide?

Tirzepatide is administered once a week via a subcutaneous injection. Don’t worry! The needle is very small and short, making self-injection quick & easy. We’ll provide you with detailed written and video instructions that make the process simple and easy to follow. We even include a link to a soothing Spotify playlist to play in the background if you wish.

More from our members
4.9/5 (2200 + 5 star reviews)
Rachel P.
"Being overweight had me feeling down and anxious all the time. Since starting semaglutide, I’ve lost 28 pounds, but what’s really amazing is how much better I feel mentally. “
Lost  28 lbs
Emily R.
"My weight gain had put a strain on my marriage, and I was feeling disconnected from my partner. Starting semaglutide was the best decision I ever made. I’ve lost 20 pounds, and my confidence has soared. My husband and I are closer than ever, and our relationship feels renewed. Willow didn’t just help me lose weight; they helped me reconnect with my spouse."
Lost  20 lbs
Sophie S.
“I've been on the Willow journey for a few months, and the results speak for themselves. Kudos to the team for a genuinely supportive experience!”
Lost  23 lbs
Tom S.
"Carrying extra weight was making it hard to enjoy hiking and biking, things I love. After starting tirzepatide, I’ve lost 35 pounds and can finally get back to being active. I can keep up with my kids now, which is the best feeling ever. Life feels good again."
Lost  35 lbs
Sarah L.
"Tirzepatide has been a total game-changer for me. In four months, I’ve lost 25 pounds, but the best part is all the extra energy I have now.”
Lost  25 lbs